He deliberately downplayed the infectiousness of the virus very early stages, and then spread anti-vaccine misinformation afterwards. As the US is a major air transport hub for, this also led to casualties in countries where it would have been a non-event. Early restrictions and screening on flights from China, then subsequent following of Fauci’s recommendations would have made a huge difference.
Someone pointed out that a lot of Latinos are effectively white, like Cruz and Rubio.