The Princess Maker series are now officially available on Steam! Unfortunately the translation quality is quite poor and the unofficial DOS copy of 2 is much better in that regard, but it’s nice to have access to multiple entries in the series now.
The most unpopular/niche game series I’ve really liked is the Princess Maker series. Japanese games which only received official English translations recently, niche genre (life raising sim), some silly fanservicey elements… but it reminded me of playing with dolls when I was younger, and in some ways the Sims series also.
Another series I liked which is much more well known but still has a small presence in the gaming consciousness is Star Fox. Character cameos in the Super Smash Bros series don’t count.
In countries with universal healthcare, there is an argument that government should take a more active role in dissuading the use of substances that cause social harm and harm to the body and result in long term expenditure for public health. The detail is in how far government should go, e.g. educational initiatives, regulation, or prohibition, etc.